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1

MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma

Hegi, Monika E., Diserens, Annie-Claire, Gorlia, Thierry, Hamou, Marie-France, de Tribolet, Nicolas, Weller, Michael, Kros, Johan M., Hainfellner, Johannes A., Mason, Warren, Mariani, Luigi, Bromberg,

Journal:

Boston Medical and Surgical Journal

Year:

2005

Language:

english

File:

PDF, 107 KB

english, 2005

2

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Roger Stupp, Monika E Hegi, Warren P Mason, Martin J van den Bent, Martin JB Taphoorn, Robert C Janzer, Samuel K Ludwin, Anouk Allgeier, Barbara Fisher, Karl Belanger, Peter Hau, Alba A Brandes, Johan

Journal:

The Lancet Oncology

Year:

2009

Language:

english

File:

PDF, 208 KB

english, 2009

3

Prognostic factors for low-grade gliomas

Roger Stupp, Robert C Janzer, Monika E Hegi, Jean-Guy Villemure, René O Mirimanoff

Journal:

Seminars in Oncology

Year:

2003

Language:

english

File:

PDF, 88 KB

english, 2003

4

Glioma epigenetics: From subclassification to novel treatment options

Gusyatiner, Olga, Hegi, Monika E.

Journal:

Seminars in Cancer Biology

Year:

2017

Language:

english

File:

PDF, 687 KB

english, 2017

5

The TICking clock of EGFR therapy resistance in glioblastoma: Target Independence or target Compensation

Saleem, Hamza, Kulsoom Abdul, U., Küçükosmanoglu, Asli, Houweling, Megan, Cornelissen, Fleur M.G., Heiland, Dieter H., Hegi, Monika E., Kouwenhoven, Mathilde C.M., Bailey, David, Würdinger, Tom, Weste

Journal:

Drug Resistance Updates

Year:

2019

Language:

english

File:

PDF, 1.58 MB

english, 2019

6

Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas

Monika E. Hegi, Axel zur Hausen, Daniela Rüedi, Gerhard Malin, Paul Kleihues

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 144 KB

english, 1997

7

Functional analyses of a unique p53 germline mutant (y236Δ) associated with a familial brain tumor syndrome

Patrick Chène, Katherine Ory, Daniela Rüedi, Thierry Soussi, Monika E. Hegi

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 112 KB

english, 1999

8

Current concepts and management of glioblastoma

Matthias Preusser, Sandrine de Ribaupierre, Adelheid Wöhrer, Sara C. Erridge, Monika Hegi, Michael Weller, Roger Stupp

Journal:

Annals of Neurology

Year:

2011

Language:

english

File:

PDF, 807 KB

english, 2011

9

Histopathologic assessment of hot-spot microvessel density and vascular patterns in glioblastoma: Poor observer agreement limits clinical utility as prognostic factors : A translational research project of the European Organization for Research and Treatment of Cancer Rrain Tumor Group

Matthias Preusser, Harald Heinzl, Ellen Gelpi, Katharina Schonegger, Christine Haberler, Peter Birner, Christine Marosi, Monika Hegi, Thierry Gorlia, Johannes A. Hainfellner

Journal:

Year:

2006

Language:

english

File:

PDF, 311 KB

english, 2006

10

Infrequent promoter methylation of the MGMT gene in liver metastases from uveal melanoma

Verena Voelter, Annie-Claire Diserens, Alexandre Moulin, Georg Nagel, Pu Yan, Eugenia Migliavacca, Donata Rimoldi, Marie-France Hamou, Bernd Kaina, Serge Leyvraz, Monika E. Hegi

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 180 KB

english, 2008

11

Comparison of pulmonary O6-methylguanine dna adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains

Theodora R. Devereux, Catherine M. White, Monika E. Hegi, Arti C. Patel, Marshall W. Anderson, Robert R. Maronpot, Julie F. Foley, Arnold Greenwell, Steven A. Belinsky

Journal:

Molecular Carcinogenesis

Year:

1993

Language:

english

File:

PDF, 913 KB

english, 1993

12

Molecular diagnostics of gliomas: the clinical perspective

Ghazaleh Tabatabai, Roger Stupp, Martin J. van den Bent, Monika E. Hegi, Jörg C. Tonn, Wolfgang Wick, Michael Weller

Journal:

Acta Neuropathologica

Year:

2010

Language:

english

File:

PDF, 318 KB

english, 2010

13

Expression of O6-methylguanine-DNA methyltransferase in childhood medulloblastoma

Denis Faoro, André O. von Bueren, Tarek Shalaby, Davide Sciuscio, Marie-Louise Hürlimann, Lucia Arnold, Nicolas U. Gerber, Johannes Haybaeck, Michel Mittelbronn, Stefan Rutkowski, Monika Hegi, Michael

Journal:

Journal of Neuro-Oncology

Year:

2011

Language:

english

File:

PDF, 440 KB

english, 2011

14

MGMTpromoter methylation in malignant gliomas

Markus J. Riemenschneider, Monika E. Hegi, Guido Reifenberger

Journal:

Targeted Oncology

Year:

2010

Language:

english

File:

PDF, 147 KB

english, 2010

15

Optimal role of temozolomide in the treatment of malignant gliomas

Roger Stupp, Martin J. van den Bent, Monika E. Hegi

Journal:

Current Neurology and Neuroscience Reports

Year:

2005

Language:

english

File:

PDF, 400 KB

english, 2005

16

Correlative studies in neuro-oncology trials: Should they influence treatment?

Monika E. Hegi, Roger Stupp

Journal:

Current Oncology Reports

Year:

2006

Language:

english

File:

PDF, 79 KB

english, 2006

17

No Complementation Between TP53 or RB-1 and v-src in Astrocytomas of GFAP-v-src Transgenic Mice

Alessia S. Maddalena, Johannes A. Hainfellner, Monika E. Hegi, Markus Glatzel, Adriano Aguzzi

Journal:

Brain Pathology

Year:

1999

Language:

english

File:

PDF, 408 KB

english, 1999

18

p73 is not Mutated in Meningiomas as Determined with a Functional Yeast Assay but p73 Expression Increases with Tumor Grade

Michimasa Nozaki, Mitsuhiro Tada, Haruhiko Kashiwazaki, Marie-France Hamou, Annie-Claire Diserens, Yumiko Shinohe, Yutaka Sawamura, Yoshinobu Iwasaki, Nicolas de Tribolet, Monika E. Hegi

Journal:

Brain Pathology

Year:

2001

Language:

english

File:

PDF, 262 KB

english, 2001

19

Molecular pathways in human glioblastoma assessed by gene expression profiling

Hegi, Monika, Nozaki, Michimasa, Labuhn, Martin, Stupp, Roger, Diserens, Annie-Claire, Hamou, Marie-France, Merlo, Adrian, de Tribolet, Nicolas, Godart, Sophie

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 38 KB

english, 2001

20

Targeting brain-tumor stem cells

Stupp, Roger, Hegi, Monika E

Journal:

Nature Biotechnology

Year:

2007

Language:

english

File:

PDF, 794 KB

english, 2007

21

Marker-independent identification of glioma-initiating cells

Clément, Virginie, Marino, Denis, Cudalbu, Cristina, Hamou, Marie-France, Mlynarik, Vladimir, de Tribolet, Nicolas, Dietrich, Pierre-Yves, Gruetter, Rolf, Hegi, Monika E, Radovanovic, Ivan

Journal:

Year:

2010

Language:

english

File:

PDF, 1.18 MB

english, 2010

22

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma

Fulci, Giulia, Labuhn, Martin, Maier, Daniel, Lachat, Yan, Hausmann, Oliver, Hegi, Monika E, Janzer, Robert C, Merlo, Adrian, Van Meir, Erwin G

Journal:

Year:

2000

Language:

english

File:

PDF, 685 KB

english, 2000

23

Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant

Klein, Michael A, Rüedi, Daniela, Nozaki, Michimasa, Dell, Elizabeth W, Diserens, Annie-Claire, Seelentag, Walter, Janzer, Robert C, Aguzzi, Adriano, Hegi, Monika E

Journal:

Year:

2000

Language:

english

File:

PDF, 545 KB

english, 2000

24

Quantitative real-time PCR does not show selective targeting of p14ARF but concomitant inactivation of both p16INK4A and p14ARF in 105 human primary gliomas

Labuhn, Martin, Jones, Graham, Speel, Ernst JM, Maier, Daniel, Zweifel, Christian, Gratzl, Otmar, Van Meir, Erwin G, Hegi, Monika E, Merlo, Adrian

Journal:

Year:

2001

Language:

english

File:

PDF, 165 KB

english, 2001

25

INK4a/Arf is required for suppression of EGFR/ΔEGFR(2-7)-dependent ERK activation in mouse astrocytes and glioma

Lachat, Yan, Diserens, Annie-Claire, Nozaki, Michimasa, Kobayashi, Hiroyuki, Hamou, Marie-France, Godard, Sophie, de Tribolet, Nicolas, Hegi, Monika E

Journal:

Year:

2004

Language:

english

File:

PDF, 349 KB

english, 2004

26

INK4a/Arf is required for suppression of EGFR/ΔEGFR(2–7)-dependent ERK activation in mouse astrocytes and glioma

Lachat, Yan, Diserens, Annie-Claire, Nozaki, Michimasa, Kobayashi, Hiroyuki, Hamou, Marie-France, Godard, Sophie, Tribolet, Nicolas de, Hegi, Monika E

Journal:

Year:

2005

Language:

english

File:

PDF, 86 KB

english, 2005

27

The mouse ERG before and after light damage is independent of p53

Nicola Lansel, Farhad Hafezi, Andreas Marti, Monika Hegi, Charlotte Remé, Günter Niemeyer

Journal:

Documenta Ophthalmologica

Year:

1998

Language:

english

File:

PDF, 202 KB

english, 1998

28

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

Weller, Michael, Stupp, Roger, Reifenberger, Guido, Brandes, Alba A., van den Bent, Martin J., Wick, Wolfgang, Hegi, Monika E.

Journal:

Nature Reviews Neurology (formerly Nature Clinical Practice Neurology)

Year:

2009

Language:

english

File:

PDF, 575 KB

english, 2009

29

A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306)

L. Burt Nabors, Thomas Mikkelsen, Monika E. Hegi, Xiaubu Ye, Tracy Batchelor, Glenn Lesser, David Peereboom, Myrna R. Rosenfeld, Jeff Olsen, Steve Brem, Joy D. Fisher, Stuart A. Grossman, for the New

Journal:

Year:

2012

Language:

english

File:

PDF, 854 KB

english, 2012

30

Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial

Monika E. Hegi, Robert-Charles Janzer, Wanyu L. Lambiv, Thierry Gorlia, Mathilde C. M. Kouwenhoven, Christian Hartmann, Andreas von Deimling, Danielle Martinet, Nathalie Besuchet Schmutz, Annie-Claire

Journal:

Acta Neuropathologica

Year:

2012

Language:

english

File:

PDF, 829 KB

english, 2012

31

Clinical Implications of Molecular Neuropathology and Biomarkers for Malignant Glioma

Tabatabai, Ghazaleh, Hegi, Monika, Stupp, Roger, Weller, Michael

Journal:

Current Neurology and Neuroscience Reports

Year:

2012

Language:

english

File:

PDF, 159 KB

english, 2012

32

Neuro-oncology: oligodendroglioma and molecular markers

Roger Stupp, Monika E Hegi

Journal:

The Lancet Neurology

Year:

2007

Language:

english

File:

PDF, 80 KB

english, 2007

33

Recent developments in the use of chemotherapy in brain tumours

Martin J. van den Bent, Monika E. Hegi, Roger Stupp

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 143 KB

english, 2006

34

New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: A pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials

Thierry Gorlia, Roger Stupp, Alba A. Brandes, Roy R. Rampling, Pierre Fumoleau, Christian Dittrich, Mario M. Campone, Chris C. Twelves, Eric Raymond, Monika E. Hegi, Denis Lacombe, Martin J. van den B

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 216 KB

english, 2012

35

Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial

Annika Malmström, Bjørn Henning Grønberg, Christine Marosi, Roger Stupp, Didier Frappaz, Henrik Schultz, Ufuk Abacioglu, Björn Tavelin, Benoit Lhermitte, Monika E Hegi, Johan Rosell, Roger Henriksson

Journal:

The Lancet Oncology

Year:

2012

Language:

english

File:

PDF, 328 KB

english, 2012

36

Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3

Thierry Gorlia, Martin J van den Bent, Monika E Hegi, René O Mirimanoff, Michael Weller, J Gregory Cairncross, Elizabeth Eisenhauer, Karl Belanger, Alba A Brandes, Anouk Allgeier, Denis Lacombe, Roger

Journal:

The Lancet Oncology

Year:

2008

Language:

english

File:

PDF, 231 KB

english, 2008

37

Treatment options in elderly patients with glioblastoma – Authors' reply

Annika Malmström, Roger Stupp, Monika Hegi, Johan Rosell, Roger Henriksson

Journal:

The Lancet Oncology

Year:

2012

Language:

english

File:

PDF, 43 KB

english, 2012

38

Brain cancer in 2012: Molecular characterization leads the way

Stupp, Roger, Hegi, Monika E.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2013

Language:

english

File:

PDF, 186 KB

english, 2013

39

Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?

Weller, Michael, Wick, Wolfgang, Hegi, Monika E, Stupp, Roger, Tabatabai, Ghazaleh

Journal:

Future Oncology

Year:

2010

Language:

english

File:

PDF, 349 KB

english, 2010

40

Molecular neuro-oncology in clinical practice: a new horizon

Weller, Michael, Pfister, Stefan M, Wick, Wolfgang, Hegi, Monika E, Reifenberger, Guido, Stupp, Roger

Journal:

The Lancet Oncology

Year:

2013

Language:

english

File:

PDF, 250 KB

english, 2013

41

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

Stupp, Roger, Hegi, Monika E, Gorlia, Thierry, Erridge, Sara C, Perry, James, Hong, Yong-Kil, Aldape, Kenneth D, Lhermitte, Benoit, Pietsch, Torsten, Grujicic, Danica, Steinbach, Joachim Peter, Wick,

Journal:

The Lancet Oncology

Year:

2014

Language:

english

File:

PDF, 569 KB

english, 2014

42

Neuro-oncology, a decade of temozolomide and beyond

Stupp, Roger, Hegi, Monika, Weller, Michael

Journal:

Expert Review of Anticancer Therapy

Year:

2010

Language:

english

File:

PDF, 393 KB

english, 2010

43

Retraction: Marker-independent identification of glioma-initiating cells

Clément, Virginie, Marino, Denis, Cudalbu, Cristina, Hamou, Marie-France, Mlynarik, Vladimir, de Tribolet, Nicolas, Dietrich, Pierre-Yves, Gruetter, Rolf, Hegi, Monika E, Radovanovic, Ivan

Journal:

Year:

2013

Language:

english

File:

PDF, 74 KB

english, 2013

44

Neuro-oncology: In search of molecular markers of glioma in elderly patients

Hegi, Monika E., Stupp, Roger

Journal:

Nature Reviews Neurology (formerly Nature Clinical Practice Neurology)

Year:

2013

Language:

english

File:

PDF, 142 KB

english, 2013

45

Genetic Alterations in Brain Tumors Following 1,3-Butadiene Exposure in B6C3F1 Mice

Kim, Yongbaek, Hong, Hue-Hua, Lachat, Yan, Clayton, Natasha, Devereux, Theodora, Melnick, Ronald, Hegi, Monika, Sills, Robert

Journal:

Toxicologic Pathology

Year:

2005

Language:

english

File:

PDF, 5.97 MB

english, 2005

46

Molecular insights into brain tumors

Hegi, Monika E.

Journal:

Current Opinion in Neurology

Year:

2013

Language:

english

File:

PDF, 132 KB

english, 2013

47

Individualized Targeted Therapy for Glioblastoma

Weller, Michael, Stupp, Roger, Hegi, Monika, Wick, Wolfgang

Journal:

The Cancer Journal

Year:

2012

Language:

english

File:

PDF, 264 KB

english, 2012

48

Detection by 32 P-postlabeling of thymidine glycol in γ-irradiated DNA

Hegi, Monika E., Sagelsdorff, Peter, Lutz, Werner K.

Journal:

Year:

1989

Language:

english

File:

PDF, 3.77 MB

english, 1989

49

Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator

Hegi, Monika E., Fox, Tony R., Belinsky, Steven A., Devereux, Theodora R., Anderson, Marshall W.

Journal:

Year:

1993

Language:

english

File:

PDF, 4.64 MB

english, 1993

50

88: An innovation for developing and validating niche-buster drugs

Virginie, Clément, Marino, Denis, Schaller, Karl, Hegi Monika, E, Radovanovic, Ivan

Journal:

Bulletin du Cancer

Year:

2010

Language:

english

File:

PDF, 58 KB

english, 2010

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